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"Peer-Reviewed Study Confirms mRNA Injections Cross The Placenta And Reach The Fetus"
The study titled, mRNA-1273 is placenta-permeable and immunogenic in the fetus, has just been accepted for publication after successful peer-review in journal Molecular Therapy Nucleic Acids:
Abstract
… In this study, mRNA-1273 intramuscularly given to pregnant mice rapidly circulated in maternal blood and crossed the placenta within one hour to spread in fetal circulation. Although spike mRNA in fetal circulation faded away within 4-6 hours, it could accumulate in fetal tissues, mainly the liver and get translated into spike protein. Transplacental mRNA-1273 proved immunogenic in the fetuses, as postnatally equipped with anti-spike IgM, paternal allotypic anti-spike IgG2a and heightened anti-spike cellular immunity. Gestationally administered, mRNA-1273 had a dose-dependent effect on its transplacental transfer and immunogenicity in the fetuses, with higher mRNA-1273 doses leading to increased transplacental mRNA-1273 passage and greater serum titers of endogenous anti-spike IgM/IgG generated by the fetuses. Thus, gestationally maternal mRNA-1273 vaccination might endow the newborns with not only passive but also active anti-spike immunity.
Here are the key findings:
Rapid Placental Transfer: The study demonstrated that mRNA-1273 crosses the placenta within one hour of maternal vaccination in a mouse model.
Accumulation in Fetal Organs: The mRNA and its lipid nanoparticle (LNP) carriers were detected in fetal blood and tissues (mainly liver), where they persisted beyond initial clearance from maternal circulation.
mRNA Translation into Spike Protein in the Fetus: Fetal tissues actively translated the vaccine mRNA into Spike protein, raising concerns about unintended immune responses or long-term biological effects.
Persistence in Fetal Liver and Spleen: mRNA remained in fetal liver and spleen for at least three weeks postnatally.
This study provides the first in vivo confirmation that mRNA injections cross the placenta, directly reaching the fetus.
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